History of Tadalafil

1107-06Like sildenafil, tadalafil is used in the treatment of erectile dysfunction. It was created after the release of sildenafil and vardenafil as the third pill used to treat erectile dysfunction and is marketed as Cialis.

How and who discovered tadalafil

Tadalafil was first discovered and developed by Galxo Wellcome while under the partnership of Biotechnology Company ICOS and then it was developed again and marketed as Cialis by Eli Lilly and Company. The two companies became a joint venture called Lilly ICOS, LLC. In December of 2003 the FDA approved tadalafil for sale in the US for the treatment of erectile dysfunction.

How Tadalafil works

Tadalafil has a 36 hour effectiveness earning the nickname “the weekend pill”. Sildenafil only has an effectiveness of four to five hours.

Like sildenafil, Tadalafil works by releasing nitric oxide into the blood relaxing the smooth muscles in the penis allowing blood to flow into the corpus cavernosum which are tubes inside the penis. Once the blood is in the penis, it allows for an erection. But unlike sildenafil, Tadalafil is taken once a day and lasts 36 hours.

The history of Tadalafil

In 1993, the Bothell, Washington, biotechnology company ICOS Corp, began studying compound IC351 which is a phosphodiesterase type 5 enzyme inhibitor or (PDE5). In 1994, Pfizer discovered that sidlenafil citrate (Viagra) caused erections in men participating in a study for heart medicine. ICOS was not using tadalafil to treat ED but found that it had potential usefulness for treating it. In 1994, ICOS received a patent for the compound IC351 which is structurally unlike sildenafil.

In 1997, clinical studies were performed on men experiencing ED and then were able to obtain the FDA’s approval. Glaxo and ICOS had an agreement and split profits 50/50 for the drug. Glaxo let the agreement lapse in 1996 and in 1998 ICOS Corporation formed a company with Eli Lilly named Lilly ICOS, LLC and together redeveloped and marketed the drug Cialis. A few years later the company filed a new drug application with the FDA for IC351 under the tadalafil generic name and the Cialis brand name.

In 2007, Eli Lilly and Company bought ICOS for 2.3 billion dollars and as a result, owned the drug tadalafil. Eli Lilly then closed down the ICOS operations and ending the joint venture.

Tadalafil interactions

As with any other type of medication, there are certain drugs you cannot take while on tadalafil. If you are taking any other type of PDE5 inhibitor, you should not take this drug. Patients taking tadalafil cannot take nitrates to relieve angina such as glyceryl trinitrate spray for at least 48 hours after taking the drug.

Tadalafil may cause hypotension which is the lowering of blood pressure, so it is not advised to take drugs such as the sex drug amyl nitrite within 48 hours because it can cause life threatening hypotension.

Tadalafil was created to help treat erectile dysfunction and was the third oral pill developed in the US to do so. It is now marketed as Cialis and has an effectiveness of up to 36 hours, well more than its competitors.


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